CONTRIBUIÇÃO DA ANÁLISE CRÍTICA SOBRE TRATAMENTOS DA INFERTILIDADE OCASIONADA POR ENDOMETRIOSE

Autores

  • Paola Gilbertoni Angelim Bisterso Centro Universitário de Adamantina
  • Francisrony Oliveira da Silveira Centro Universitário de Adamantina
  • Maria Solange Lima de Souza Centro Universitário de Adamantina
  • Vanderli Aparecida Andrade Cavalcante Centro Universitário de Adamantina
  • Nildo Redivo Júnior Centro Universitário de Adamantina

DOI:

https://doi.org/10.69719/ros.v7iesp..807

Palavras-chave:

Endometriose, Infertilidade, Tratamento, Análise Crítica

Resumo

Este trabalho tem como objetivo realizar uma análise crítica dos tratamentos para infertilidade causada por endometriose, avaliando a eficácia das abordagens terapêuticas com base em estudos clínicos randomizados e controlados. Foi conduzida uma revisão sistemática da literatura em bases de dados como PubMed, Scopus e Web of Science. Os critérios de inclusão consideraram estudos clínicos randomizados e controlados publicados entre 2013 e 2023, que investigassem tratamentos para infertilidade em mulheres com endometriose. Foram excluídos estudos que não apresentassem dados quantitativos claros ou que estivessem fora do escopo de análise. A extração dos dados focou em resultados como taxas de gravidez, melhoria nos sintomas e segurança dos tratamentos. Ao todo foram pesquisados 40 artigos nestas plataformas, sendo selecionados apenas 11. A análise crítica dos estudos selecionados sobre o tratamento da infertilidade relacionada à endometriose demostrou uma variedade de abordagens com resultados diferentes. Alguns tratamentos, como a administração de atosiban antes da transferência de embriões congelados, astaxantina para técnicas de reprodução assistida e implantação assistida por laser em ICSI-ET, mostraram melhorias significativas na gravidez e eficácia no tratamento da infertilidade. No entanto, tratamentos como a administração pré-FIV de Lipiodol®, progestágenos em cotratamento com hMG e GnRHa antes da fertilização in vitro não proporcionaram benefícios substanciais, indicando a necessidade de avaliação cuidadosa dessas intervenções na prática clínica. A medicina reprodutiva é um campo dinâmico e a individualização do tratamento, considerando as características específicas do paciente, é essencial para o sucesso do tratamento da infertilidade ocasionada pela endometriose

Referências

Acién P, Velasco I. Endometriosis: a disease that remains enigmatic. ISRN Obstet Gynecol. 2013;2013:242149. DOI: https://doi.org/10.1155/2013/242149

Alimi Y, Iwanaga J, Loukas M, Tubbs RS. The clinical anatomy of endometriosis: A review. Cureus. 2018;10(9):e3361. DOI: https://doi.org/10.7759/cureus.3361

Arafah M, Rashid S, Akhtar M. Endometriosis: A comprehensive review. Adv Anat Pathol. 2021;28(1):30–43. DOI: https://doi.org/10.1097/PAP.0000000000000288

Critchley HOD, Maybin JA, Armstrong GM, Williams ARW. Physiology of the endometrium and regulation of menstruation. Physiol Rev. 2020;100(3):1149–79. DOI: https://doi.org/10.1152/physrev.00031.2019

Borumandnia N, Alavi Majd H, Khadembashi N, Alaii H. Worldwide trend analysis of primary and secondary infertility rates over past decades: A cross-sectional study. Int J Reprod Biomed (Yazd). 2022;20(1):37–46. DOI: https://doi.org/10.18502/ijrm.v20i1.10407

Asghari S, Valizadeh A, Aghebati-Maleki L, Nouri M, Yousefi M. Endometriosis: Perspective, lights, and shadows of etiology. Biomed Pharmacother. 2018;106:163–74. DOI: https://doi.org/10.1016/j.biopha.2018.06.109

Laganà AS, Garzon S, Götte M, Viganò P, Franchi M, Ghezzi F, et al. The pathogenesis of endometriosis: Molecular and cell biology insights. Int J Mol Sci. 2019;20(22):5615. DOI: https://doi.org/10.3390/ijms20225615

Bazot M, Daraï E. Diagnosis of deep endometriosis: clinical examination, ultrasonography, magnetic resonance imaging, and other techniques. Fertil Steril. 2017;108(6):886–94. DOI: https://doi.org/10.1016/j.fertnstert.2017.10.026

Zhang X, He T, Shen W. Comparison of physical examination, ultrasound techniques and magnetic resonance imaging for the diagnosis of deep infiltrating endometriosis: A systematic review and meta-analysis of diagnostic accuracy studies. Exp Ther Med. 2020;20(4):3208–20. DOI: https://doi.org/10.3892/etm.2020.9043

Vannuccini S, Clemenza S, Rossi M, Petraglia F. Hormonal treatments for endometriosis: The endocrine background. Rev Endocr Metab Disord. 2022;23(3):333–55. DOI: https://doi.org/10.1007/s11154-021-09666-w

Lee D, Kim SK, Lee JR, Jee BC. Management of endometriosis-related infertility: Considerations and treatment options. Clin Exp Reprod Med. 2020;47(1):1–11. DOI: https://doi.org/10.5653/cerm.2019.02971

Batt R. A History of Endometriosis. 2011th ed. London, England: Springer; 2014. 226 p. DOI: https://doi.org/10.1007/978-0-85729-585-9

Benagiano G, Brosens I, Lippi D. The history of endometriosis. Gynecol Obstet Invest. 2014;78(1):1–9. DOI: https://doi.org/10.1159/000358919

Jones CE. Wandering wombs and “female troubles”: The hysterical origins, symptoms, and treatments of endometriosis. Womens Stud. 2015;44(8):1083–113. DOI: https://doi.org/10.1080/00497878.2015.1078212

Smolarz B, Szyłło K, Romanowicz H. Endometriosis: Epidemiology, classification, pathogenesis, treatment and genetics (review of literature). Int J Mol Sci. 2021;22(19):10554. DOI: https://doi.org/10.3390/ijms221910554

Brosens I, Benagiano G. History of endometriosis: A 20th-century disease. In: Endometriosis. Oxford, UK: Wiley-Blackwell; 2012. p. 1–18. DOI: https://doi.org/10.1002/9781444398519.ch1

Terzic M, Aimagambetova G, Kunz J, Bapayeva G, Aitbayeva B, Terzic S, et al. Molecular basis of endometriosis and endometrial cancer: Current knowledge and future perspectives. Int J Mol Sci. 2021;22(17):9274. DOI: https://doi.org/10.3390/ijms22179274

Kim M-R, Chapron C, Römer T, Aguilar A, Chalermchockcharoenkit A, Chatterjee S, et al. Clinical diagnosis and early medical management for endometriosis: Consensus from Asian expert group. Healthcare (Basel). 2022;10(12):2515. DOI: https://doi.org/10.3390/healthcare10122515

Tomassetti C, D’Hooghe T. Endometriosis and infertility: Insights into the causal link and management strategies. Best Pract Res Clin Obstet Gynaecol. 2018;51:25–33. DOI: https://doi.org/10.1016/j.bpobgyn.2018.06.002

Simopoulou M, Rapani A, Grigoriadis S, Pantou A, Tsioulou P, Maziotis E, et al. Getting to know endometriosis-related infertility better: A review on how endometriosis affects oocyte quality and embryo development. Biomedicines. 2021;9(3):273. DOI: https://doi.org/10.3390/biomedicines9030273

Filip L, Duică F, Prădatu A, Crețoiu D, Suciu N, Crețoiu SM, et al. Endometriosis associated infertility: A critical review and analysis on etiopathogenesis and therapeutic approaches. Medicina (Kaunas). 2020;56(9). DOI: https://doi.org/10.3390/medicina56090460

Gruber TM, Mechsner S. Pathogenesis of endometriosis: The origin of pain and subfertility. Cells. 2021;10(6):1381. DOI: https://doi.org/10.3390/cells10061381

Agarwal N, Subramanian A. Endometriosis - morphology, clinical presentations and molecular pathology. J Lab Physicians. 2010;2(1):1–9. DOI: https://doi.org/10.4103/0974-2727.66699

Mahdavinezhad F, Gharaei R, Farmani AR, Hashemi F, Kouhestani M, Amidi F. The potential relationship between different human female reproductive disorders and sperm quality in female genital tract. Reprod Sci. 2022;29(3):695–710. DOI: https://doi.org/10.1007/s43032-021-00520-7

Máté G, Bernstein LR, Török AL. Endometriosis is a cause of infertility. Does reactive oxygen damage to gametes and embryos play a key role in the pathogenesis of infertility caused by endometriosis? Front Endocrinol (Lausanne). 2018;9:725. DOI: https://doi.org/10.3389/fendo.2018.00725

Carvalho LFP, Rossener R, Azeem A, Malvezzi H, Simões Abrão M, Agarwal A. From conception to birth - how endometriosis affects the development of each stage of reproductive life. Minerva Ginecol. 2013;65(2):181–98.

Evans MB, Decherney AH. Fertility and endometriosis. Clin Obstet Gynecol. 2017;60(3):497–502. DOI: https://doi.org/10.1097/GRF.0000000000000295

Sanchez AM, Vanni VS, Bartiromo L, Papaleo E, Zilberberg E, Candiani M, et al. Is the oocyte quality affected by endometriosis? A review of the literature. J Ovarian Res. 2017;10(1). DOI: https://doi.org/10.1186/s13048-017-0341-4

Kolanska K, Alijotas-Reig J, Cohen J, Cheloufi M, Selleret L, d’Argent E, et al. Endometriosis with infertility: A comprehensive review on the role of immune deregulation and immunomodulation therapy. Am J Reprod Immunol. 2021;85(3):e13384. DOI: https://doi.org/10.1111/aji.13384

Miller JE, Ahn SH, Monsanto SP, Khalaj K, Koti M, Tayade C. Implications of immune dysfunction on endometriosis associated infertility. Oncotarget. 2017;8(4):7138–47. DOI: https://doi.org/10.18632/oncotarget.12577

Vallvé-Juanico J, Houshdaran S, Giudice LC. The endometrial immune environment of women with endometriosis. Hum Reprod Update. 2019;25(5):564–91. DOI: https://doi.org/10.1093/humupd/dmz018

Decleer W, Osmanagaoglu K, Verschueren K, Comhaire F, Devroey P. RCT to evaluate the influence of adjuvant medical treatment of peritoneal endometriosis on the outcome of IVF. Hum Reprod. 2016;31(9):2017–23. DOI: https://doi.org/10.1093/humrep/dew148

Guo H, Li J, Shen X, Cong Y, Wang Y, Wu L, et al. Efficacy of different progestins in women with advanced endometriosis undergoing controlled ovarian hyperstimulation for in vitro fertilization-A single-center non-inferiority randomized controlled trial. Front Endocrinol (Lausanne). 2020;11. DOI: https://doi.org/10.3389/fendo.2020.00129

Rodríguez-Tárrega E, Monzo AM, Quiroga R, Polo-Sánchez P, Fernández-Colom P, Monterde-Estrada M, et al. Effect of GnRH agonist before IVF on outcomes in infertile endometriosis patients: a randomized controlled trial. Reprod Biomed Online. 2020;41(4):653–62. DOI: https://doi.org/10.1016/j.rbmo.2020.06.020

Kaponis A, Chatzopoulos G, Paschopoulos M, Georgiou I, Paraskevaidis V, Zikopoulos K, et al. Ultralong administration of gonadotropin-releasing hormone agonists before in vitro fertilization improves fertilization rate but not clinical pregnancy rate in women with mild endometriosis: a prospective, randomized, controlled trial. Fertil Steril. 2020;113(4):828–35. DOI: https://doi.org/10.1016/j.fertnstert.2019.12.018

He Y, Wu H, He X, Xing Q, Zhou P, Cao Y, et al. Administration of atosiban in patients with endometriosis undergoing frozen–thawed embryo transfer: a prospective, randomized study. Fertil Steril. 2016;106(2):416–22. DOI: https://doi.org/10.1016/j.fertnstert.2016.04.019

Zhou L, Fu J, Liu D, Wang Q, Chen H, Yang S, et al. Ovulation induction with clomiphene citrate or letrozole following laparoscopy in infertile women with minimal to mild endometriosis: a prospective randomised controlled trial. J Obstet Gynaecol. 2022;42(2):316–21. DOI: https://doi.org/10.1080/01443615.2021.1904224

Rostami S, Alyasin A, Saedi M, Nekoonam S, Khodarahmian M, Moeini A, et al. Astaxanthin ameliorates inflammation, oxidative stress, and reproductive outcomes in endometriosis patients undergoing assisted reproduction: A randomized, triple-blind placebo-controlled clinical trial. Front Endocrinol (Lausanne). 2023;14. DOI: https://doi.org/10.3389/fendo.2023.1144323

Nada AM, El-Noury A, Al-Inany H, Bibars M, Taha T, Salama S, et al. Effect of laser-assisted zona thinning, during assisted reproduction, on pregnancy outcome in women with endometriosis: randomized controlled trial. Arch Gynecol Obstet. 2018;297(2):521–8. DOI: https://doi.org/10.1007/s00404-017-4604-5

Navali N, Gassemzadeh A, Farzadi L, Abdollahi S, Nouri M, Hamdi K, et al. Intrauterine administration of hCG immediately after oocyte retrieval and the outcome of ICSI: a randomized controlled trial. Hum Reprod. 2016;31(11):2520–6. DOI: https://doi.org/10.1093/humrep/dew236

Iriart JAB. Medicina de precisão/medicina personalizada: análise crítica dos movimentos de transformação da biomedicina no início do século XXI. Cad Saude Publica. 2019;35(3). DOI: https://doi.org/10.1590/0102-311x00153118

Reilly SJ, Glanville EJ, Dhorepatil B, Prentice LR, Mol BW, Johnson NP. The IVF-LUBE trial – a randomized trial to assess Lipiodol® uterine bathing effect in women with endometriosis or repeat implantation failure undergoing IVF. Reprod Biomed Online. 2019;38(3):380–6. DOI: https://doi.org/10.1016/j.rbmo.2018.11.015

Fawzy M, Emad M, Mahran A, Abdelrahman MY, Fetih AN, Abdelghafar H, et al. A randomized controlled trial of laser-assisted ICSI. Hum Reprod. 2020;35(12):2692–700. DOI: https://doi.org/10.1093/humrep/deaa160

Downloads

Publicado

22/11/2024

Como Citar

Gilbertoni Angelim Bisterso, P., Oliveira da Silveira, F., Lima de Souza, M. S., Andrade Cavalcante, V. A., & Redivo Júnior , N. (2024). CONTRIBUIÇÃO DA ANÁLISE CRÍTICA SOBRE TRATAMENTOS DA INFERTILIDADE OCASIONADA POR ENDOMETRIOSE. Revista OMNIA Saúde, 7(esp.), 114–123. https://doi.org/10.69719/ros.v7iesp.807

Artigos Semelhantes

<< < 6 7 8 9 10 11 

Você também pode iniciar uma pesquisa avançada por similaridade para este artigo.

Artigos mais lidos pelo mesmo(s) autor(es)